Sep 17
Authors:

David Bentley, Belle Roels, Claire Thomas, Robert Ives, Jacques Mercier, Grégoire Millet, David Cameron-Smith

The purpose of this study was to examine the relationship between skeletal muscle monocarboxylate transporters 1 and 4 (MCT1 and MCT4) expression, skeletal muscle oxidative capacity and endurance performance in trained cyclists. Ten well-trained cyclists (mean +/- SD; age 24.4 +/- 2.8 years, body mass 73.2 +/- 8.3 kg, VO(2max) 58 +/- 7 ml kg(-1) min(-1)) completed three endurance performance tasks [incremental exercise test to exhaustion, 2 and 10 min time trial (TT)]. In addition, a muscle biopsy sample from the vastus lateralis muscle was analysed for MCT1 and MCT4 expression levels together with the activity of citrate synthase (CS) and 3-hydroxyacyl-CoA dehydrogenase (HAD). There was a tendency for VO(2max) and peak power output obtained in the incremental exercise test to be correlated with MCT1 (r = -0.71 to -0.74; P < 0.06), but not MCT4. The average power output (P (average)) in the 2 min TT was significantly correlated with MCT4 (r = -0.74; P < 0.05) and HAD (r = -0.92; P < 0.01). The P (average) in the 10 min TT was only correlated with CS activity (r = 0.68; P < 0.05). These results indicate the relationship between MCT1 and MCT4 as well as cycle TT performance may be influenced by the length and intensity of the task.

European journal of applied physiology. 01/04/2009;

FULL ARTICLE

http://www.researchgate.net/researcher/38177302_Belle_Roels

Sep 15

The problem of hypoxia is a multi-headed Medusa in physiology and clinical medicine. Two main aspects of this problem are hotly discussed: the destructive and the constructive action of hypoxia. One viewpoint belonging primarily to western scientists is perfectly expressed in Barcroft’s words: “Hypoxia not only intercepts the machine, but also damages the mechanism”. The second veiwpoint, expressed primarily by the former Soviet Union (FSU) scientific schools, reads as follows: “Hypoxia (even severe but brief and intermittent) can cause beneficial effects on an organism”. However, many a scientific publication was in Russian or Ukrainian and because they were not widely available in other countries, these research findings remained obscure. The purpose of this review is to summarize some past and recent achievements in the field of intermittent hypoxic training (IHT), giving special consideration to applied problems in the treatment of bronchial asthma (BA).

Historical aspects

Historically, first steps in the use of IHT were for training pilots, mountaineers and athletes. The pioneering research, carried out in 1939-1943 (see 1 for review), showed that even a small altitude elevation produces positive adaptation effect, improving lung ventilation and increasing hemoglobin concentration and arterial oxygen saturation. The research of the time drew attention not only to constructive and creative hypoxic training but also to possible curative effects of hypoxic adaptation. More than 30 years later, other studies have shown that a training protocol that includes gradual adaptation to hypobaric hypoxia improves the working capacity and endurance of athletes and astronauts. Inhalation of hypoxic gas mixtures to produce IHT was rapidly introduced into sports training and diseases treatment procedures. IHT protocols and equipment were devised and manufactured for this purpose.

FULL ARTICLE

Sep 1

2010 by Oleg Bassovitch

Recently published Letter to the Editor titled “Intermittent hypoxic training: risks versus benefits” (Hinghofer-Szalkay, 2010) suggested inquiring into the  long-term risks of Intermittent Hypoxic Training” (IHT), that is also called Therapeutic Hypoxia (TH). The letter points at potential risk of Reactive Oxygen Species (ROS) formation. From the biomedical point of view it is important to separate hazards associated with the use of a device / system and physiological risks and benefits of the therapy itself.

Undoubtfully, a device for human or animal treatments must be meeting essential requirements for medical devices e.g. electrical medical safety and electromagnetic compatibility (IEC 60601-1, 2007).

Devices and systems for hypoxia intervention are called “hypoxicators” and were recently suggested by Australian Therapeutic Goods Administration being mandatory regulated for all applications (TGA, 2008). Hypoxicator falls under the common definition of medical device because of it intended use e.g. “modification of physiological process” (Council Directive 93/42/EEC, 1993).

This letter is a brief review of physiological risks associated with the use of hypoxicators and IHT for human performance enhancement, in both athletic and sedentary populations.

ACCESS TO FULL ARTICLE

http://www.springerlink.com/content/4632×38184754513/

Aug 20

The outcomes of reside lower with sporadic subjection to hypoxia, train reduced instruction on efficiency of cyclists are discussed right here.

Ongoing subjection to natural elevation may increase complications for the hurt athlete as well as common recovery could get slowed. The endurance athlete has being provided accurate time periods of recovery following each and every stress workout. Numerous higher performing altitude training camps get the better of cyclists from climbing down to coast level to get high intensity training purpose.

The objective of height training plans is always to improve conditioning ranges in participants either by providing raises ranges of tension in the course of the training sessions or recovery or decreased amounts of stress.Bike riders who get involved within competition come across different training troubles when of working on altitude training. A smart rider or a trainer can be aware of timings of elevation training throughout the season in order that he or she might obtain optimum advantages out of the education plan.

A good fitness instructor has to accomplish bunch of analysis throughout the program with the altitude base exercising towards the best suited cyclist.

Typically the injured athletes might obtain more gains by working the simulated over sea riding because of better heart reply for decreased potential result.Every single physical education practice session induces variation from the rider for the environment and they accomplish the conditioning plateau. A well organized improve within the tension values with the strength exercising lead the rider to greater overall performance.The cyclist who is avoided from increased energy outputs at seaside degree can certainly work out at a high elevation to attain comparatively large core rates.

Better sea level performance may be as a result of elevated EPO release by filtering system, higher red cell mass and highest breathable air assimilation by muscle groups.Irregular hypoxic exposure does alter hematocrit, and alsoperformance during sleep, proving its effectiveness. Endurance training at increased altitudes raises the content level of blood cells and non-hematological results.Increase in plasma level (hemoconcentration) which happens next to the altitude training is incorrectly recognized for increased cellular size.

A note about EPO (Erythropoietin)

Treatments of EPO are unquestionably banned wordwide and result in thickening associated with bloodstream and even heart failure. Get better educated in relation to EPO before deciding these banned actions. Cyclists or runners will improve their overall performance by understanding a little more about complete book of road bike training

Scientists have done a lot of studies and written evaluations on altitude training being a approach supporting to different athletic divisions of sport science.

Advanced long distance runners, demonstrated better sea level efficiency by one.One percent, consequently of the week’s “live high, practice low” technique. Australian experts have detected better activities by “live high” technique with out any kind of increases in reddish colored blood cell mass or maybe increased air expire, realizing their thoughts and opinions that results is improved with height training which can be separate from breathable air expiration.Experts associated with this technique think this a clear placebo-handled device offers not been formed yet.

Concrete facts does not be found promoting the flexibility associated with irregular hypoxia exposure.Paperwork Accessible On Altitude Exercising. Another researcher stated the fact that professional sports researcher coming from Sydney have demostrated profound curiosity on that procedure that is a method associated with height exercise.In the year late 2001, the two scientists stated that the particular ,”live higher, train low” technique in elevation workouts was initially highly successful for athletes taking part in four hundred track race.Wilber published a couple of reviews reports about the evaluation of various high level exercising methods practiced by triathletes which represent diverse competitions. published obvious and evaluations about elevation training of which was go through and got achieved positive results by the riders and their trainers who took portion within world competitors.

SOURCE

Jul 3
Altitude preexposure acclimatization
icon1 admin | icon2 Mountaineering, Sports | icon4 07 3rd, 2010| icon3Comments Off

Abstract
———-
Muza, Stephen R., Beth A. Beidleman, and Charles S Fuco. Altitude preexposure recommendations for inducing acclimatization. High Alt. Med.Biol. 11:87-92, 2010.-For many low-altitude (<1500 m) residents, their travel itineraries may cause them to ascend rapidly to high (>2400 m) altitudes without having the time to develop an adequate degree of altitude acclimatization. Prior to departing on these trips, low-altitude residents can induce some degree of altitude acclimatization by ascending to moderate >1500 m) or high altitudes during either continuous or intermittent altitude preexposures. Generally, the degree of altitude acclimatization developed is proportional to the altitude attained and the duration of exposure. The available evidence suggests that continuous residence at 2200m or higher for 1 to 2 days or daily 1.5- to 4-h exposures to >4000m induce ventilatory acclimatization. Six days at 2200m substantially decreases acute mountain sickness (AMS) and improves work performance after rapid ascent to 4300 m. There is evidence that 5 or more days above 3000m within the last 2 months will significantly decrease AMS during a subsequent rapid ascent to 4500 m. Exercise training during the altitude preexposures may augment improvement in physical performance. The persistence of altitude acclimatization after return to low altitude appears to be proportional to the degree of acclimatization developed. The subsequent ascent to high altitude should be scheduled as soon as possible after the last altitude preexposure.
Key Words:  altitude acclimatization; acute mountain sickness; high altitude

Link to Full article

Jun 25

Object: The hypoxic training methods are widely studied since 1968. But different training styles may cause different results.Heart is an important part of kinetic system. Hypoxia acclimatization,especially under the process of exercise could lead lots of physiological changes that propitious to aerobic capability. We studied the effect of hypoxic on the myocardial ultrastructure and aerobic oxidation function of rest and training rats in order to make full realize of the HiLo training on bodies.Materials and Methods:140 male Spargue-Dawley rats were randomly divided into 4 groups: normoxia control group(N),intermittent hypoxic group(H),normoxia training group(T) and HiLo group(HT).N and T are both divided into 3 sub-groups as the time that lday,7days and 28days;H and HT are both divided into 4 sub-groups as the time that lday、7day、8days and 7days after the intermittent hypoxic.Therefore there are totally 14 sub-groups, each one with 10 rats.After all the groups had been adapted for one week, the T and HT performed closely monitored training in treadmills(grade of 5,at the speed of 20m/min,duration of lh/day,6 days/week) for 4 weeks;the last HT group performed one more week after the hypoxia training.(All the trainings are out of the tent) During the 4 weeks experimental period,we employed the 13.6%concentration of oxygen(equal to altitude 3500m) in the hypoxic tent.H and HT groups were exposed to hypoxia for 12h every day.Sample collection and measurements were performed when the hypoxic groups just got out of the tent.The indexes we measured contains that the ATP synthase activity,the LDH synthase activity,the SDH synthase activity of myocardial.and the morphological observation. 1.In contrast to the N groups,the ATP synthase activity of myocardial increased significantly in the H groups;In the T groups,there was slightly decrease in the lday sub-group.And it respectively increased 7.9%and 32.2%in the 7days and 28days sub-groups;In the HT groups,it increased 40.7%,92.9%and 109.2%in the 7days,28days and 7days after the intermittent hypoxic sub-groups respectively.2.In contrast to the N groups,the LDH synthase activity of myocardial had just a slightly increased in all the intermittent hypoxic sub-groups; In the T groups,it increased 6.5%and 8.4%in the 7days and 28days sub-groups respectively;In the HT groups,it respectively increased 8.6%,13.8%,16.3%in the 7days,28days and 7days after the intermittent hypoxic sub-groups.In addition,the LDH synthase activity of myocardial slightly decreased in lday sub-groups of T and HT.3.In contrast to the N groups,the SDH synthase activity of myocardial respectively increased 31.4%,12.7%and 23.7;5.0%and 24.6%;34.5%, 61.8%and 75.9%in H,NT and HTs’ 7days,28days and 7days after the intermittent hypoxic sub-groups.4.Myocardial ultrastructure of mitochondria,myofibrils and myofilament were observed by transmission electron microscope.The results show that HiLo training could improve ultrastructure of mitochondria,myofibrils and myofilament.Therefore the aerobic metabolism ability and energy utilization would be strengthened as a result.Conclusion:1.During the process of 4 weeks HiLo and 1 week training after HiLo, the SDH synthase, LDH synthase and ATP synthase activity of myocardial increased obviously as time passes by. The results show that HiLo training can improve the myocardial synthase ability,hence strengthen the myocardial aerobic oxidation effectively.  2.The hypoxia acclimatization and endurance training of 4 weeks can improve the myocardial ultrastructure,making the mitochondria get more and the density of mitochondrial crista get high.The aerobic metabolism ability got strongly impoved,especially during the days after the intermittent hypoxic.

Source:

Jun 18

Acute Intermittent Hypoxia on Spinal Plasticity The objective of this study is to examine the effects of repeated episodes of mild acute intermittent hypoxia (AIH) on motoneuron activity in persons with incomplete spinal cord injury (SCI). In particular, we will quantify the effects of repeated exposure to AIH on limb muscle activity, and determine if changes in the observed muscle responses are accompanied by enhanced voluntary torque strength and walking performance. If true, such changes may indicate hypoxia-induced spinal plasticity resulting in functionally useful enhancement of motor output. Findings from this project could offer new insight into a possible mechanism of neuromodulation of spinal motoneuron pools and recovery of neuromotor function following SCI.

Jun 8

At the Royal Bafokeng Stadium on Saturday England play the USA at 1,500m, a few minutes’ drive from the Rustenburg training base used by Capello’s team. Before flying to the country the Italian and his opposite number, Bob Bradley, chose contrasting approaches.

The USA decided not to train at altitude before departing, while England spent two weeks playing and training in the Austrian Alps. The director of London’s Altitude Centre, Richard Pullen, who advised Capello and the Football Association on how best to prepare the England squad, said: “The Americans have not done any preparation at all. This is so that they could have full‑on training sessions and arrive very fit, yet unacclimatised. They have taken a gamble on their fitness being enough to see them through.

“The other way [is to] get acclimatised to altitude so your training and recovery can be impaired and when [the team] arrive you’re not completely as fit as you might be. But you are adapted.”

It is 24 years since a World Cup featured stadiums above sea level and Diego Maradona’s Argentina – who unlike some nations at Mexico ‘86 played all their games at altitude – emerged as eventual winners. As every nation during the group phase will play games at sea level and on the Highveld all have had to ensure preparation has been thorough this time.

“If you see a map of where all teams are based you’ll see it’s at altitude,” Pullen said. “For England or any team that goes to altitude – the first couple of days the training load is reduced while the players get used to it and then [they] slowly increase the load to the maximum.”

Pullen does say that despite the fortnight in the Alps, conditions were not perfect as the ideal stepping stone to Rustenburg, which is much higher than Irdning. “Austria was in all the newspapers as being an altitude training camp. In reality they were at 600m. But they did use an altitude kit, which simulates higher altitudes. So in Austria they had access to testing equipment to have their bodies physiologically adapted to the higher altitude they’ll experience in South Africa. But what they haven’t done is prepare for the dynamics of how the ball will move differently, and the drier air – the environmental conditions they’ll find in Rustenburg.”

Becoming familiar with a faster, more unpredictable ball is as imperative as ensuring Capello’s squad rest correctly. “Recovery is not just about sleeping, it is about active recovery, about making sure players have recovered from training sessions,” Pullen said. “There will be monitoring to make sure players are eating properly, hydrating properly, because at altitude you can lose appetite. It’s very important that they look after their health properly.”

Players and footballs have altered experiences in rarefied air due to the reduction in oxygen found at altitude. “Basically as you go up your body tries to produce more red blood cells to be able to transport oxygen around the body,” said Oxford University’s Dr Patrick McSharry. “This means that at high altitudes some people get acute symptoms like nausea, sickness, headaches, lots of horrible things that wouldn’t make it easy to compete in football.”

But it is difficult to know which players will suffer more. “One of the problems is that it seems to vary greatly from person to person so you can’t just predict what will happen to the whole team,” McSharry said. “Some members may be completely fine, others severely impacted.”

Whatever the vagaries Pullen is confident that Capello and England have prepared correctly by leaving themselves nine days between arrival and kicking off against the USA. “They’ve been doing the training in Austria with our equipment and have gone there with plenty of time ahead of the first match,” he said. “And, they’re playing it at the same altitude as where they’re based – so it’s very good.”

Radebe, however, suggested that the USA may still have an edge because of their experience when reaching the Confederations Cup final in South Africa last summer. “America have been here before and the coach knows the conditions,” he said. On Saturday England will begin to find out how well they are adapted.

FULL STORY

Jun 6

Tuesday, June 1st, 2010

What is Altitude Training?

Altitude training, also known as hypoxic training, involves exercising in, living in or otherwise breathing oxygen reduced air for the purpose of improved athletic performance, pre-acclimatization to altitude and/or physical wellness.

Traditionally, individuals had to travel to or live at high elevations to obtain the benefits of this phenomenon. Through the production of the mountain air generators we can simulate altitudes of up to 21,000ft/6,400m. As a result, athletes, fitness enthusiasts and health conscious individual’s worldwide can take advantage of the benefits associated with altitude training while at sea-level.
Proven Benefits
. Maximized speed and endurance
. Elevated strength and power

SOURCE

Jun 4

Lippi blamed fatigue for the Azzurri’s loss.

By Salvatore Landolina

Jun 3, 2010 3:15:00 PM

Marcello Lippi - Italy (Getty Images)

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Marcello Lippi - Italy (Getty Images)

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Italy coach Marcello Lippi has played down the 2-1 defeat to Mexico by shifting the spotlight from a lackluster performance to a hard training regime.

Carlos Vela and Alberto Medina ensured the Azzurri’s pre-World Cup preparations got off to the worst possible start. Leonardo Bonucci cut the deficit, but it was not enough.

“We have been in the mountains training for 10 days and we have just come back to play a against a team in much better condition than we are and who have played seven times already, and you have to take that into account,” Lippi told Rai Sport.

Lippi though remains defiant that his Azzurri stars will be ready for the World Cup, claiming the altitude training has shown its effects tonight as the players struggled.

“I know my players, I have spoken to them and they told me they were tired before the game. What’s important is to be in good condition in 10 days when we are in South Africa, not now.

“If we had played seven games like they did then we would have been in better condition.”

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