[Effect of adaptation to hypoxia on the antioxidant enzyme
activity in the liver in animals that have undergone stress].
[Article in Russian]
Tverdokhlib VP, Konovalova GG, Lankin VZ, Meerson FZ
It was shown in experiments on rats that emotional-painful stress resulted
in a rapid increase in
malonic dialdehyde (MDA) and in a decrease in the activity of superoxide
dismutase (SOD) in liver.
Adaptation to moderate intermittent hypoxia in altitude chamber did
not affect MDA and increased
hepatic SOD by 65%. Stress exposure caused no change in SOD and MDA,
but abruptly reduced
the fall of SOD in adapted animals. These data are in accordance with
the well-known idea that
adaptation to hypoxia prevents the activation of lipid peroxidation
and the hepatic damage in stress.