Does a moderate hypoxia induce manganese-superoxide
dismutase or heat shock proteins to act as possible
protective factors?
Pohle W, Rauca C
Department of Pharmacology and Toxicology, Faculty of Medicine of the
Otto-von-Guericke-University, Magdeburg, Germany.
Male Wistar rats were kept in a hypoxia chamber (9% O2) for eight hours.
Control animals
breathed room air in the same chamber for a similar period of time.
One week later the brains of all
rats were prepared for the immunohistochemical demonstration of Mn-superoxide
dismutase
(Mn-SOD). In comparison with the sham-exposed controls, the hypoxia-treated
animals showed an
increase in the number of Mn-SOD-immunoreactive neurons in several
hippocampal structures. The
72 kD heat shock protein was not found to be induced one week after
a moderate hypoxia.